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KMID : 1143420210140181092
Public Health Weekly Report
2021 Volume.14 No. 18 p.1092 ~ p.1098
Status of adverse reactions after COVID-19 vaccination in the Republic of Korea, February 26, 2021-March 25, 2021
Oh Hyun-Kyung

Lee Yeon-Kyeong
Kim Tae-Eun
Lee Eun-Ju
Park Sook-Kyung
Abstract
Coronavirus disease (COVID-19) spread throughout the world after first being reported in Wuhan, China in December 2019.
As of now (April 6, 2021), there have been around 130,000,000 confirmed cases and 2,850,000 deaths. Countries have
employed various strategies to limit the spread of COVID-19, such as patient detection (diagnostic testing), patient and
contact management, mask wearing, and social distancing, but due to continued new cases and spread, vaccines have
become an important strategy for controlling COVID-19. Various countries invested efforts in developing and procuring
COVID-19 vaccines, and on December 8, 2020, COVID-19 vaccination began for the first time in the world in the United
Kingdom. However, unintended adverse effects can occur after vaccination, so each country has been evaluating the safety of the vaccines through strengthened monitoring. Monitoring of adverse events following COVID-19 immunization in South Korea is based on the standard monitoring system through which doctors report adverse events according to the Infection Disease Control and Prevention Act, as well as monitoring of individuals who agreed to receive texts to monitor adverse events during their immunization screening.
COVID-19 vaccination began on February 26, 2021 in South Korea, and 773,262 individuals have been vaccinated in the first
month (as of March 25, 2021). In total, 10,103 adverse events were reported. More reports of adverse events were made by
women than by men, and more adverse events were reported by younger individuals. Almost all (98.8%; 9,982 cases) of the reported adverse events were general symptoms which may occur after vaccination (e.g., muscle aches or headaches). Muscle aches were the most common reported symptoms (60.7%), followed in order by fever (57.6%), headaches (39.2%), and nausea (20.7%). Only 2.8% (21,433) of the 773,262 individuals who received COVID-19 vaccination agreed to receive texts and responded to them. Of those individuals, 32.9% reported discomfort after vaccination, and younger respondents reported discomfort at a higher proportion. The main symptoms were pain in the injection site (26.9%), muscle aches (23.8%), fatigue (22.5%), headache (19.9%), chills (17.9%), and fever (16.4%). In South Korea, safe vaccination is promoted through immunization screening, monitoring of adverse events through various methods, rapid response and epidemiological investigations following adverse events, and national vaccine injury compensation program. To return to our daily lives, we should all actively participate in COVID-19 vaccination and monitoring of adverse events after COVID-19 vaccination.
KEYWORD
COVID-19 vaccination, Adverse events following immunization (AEFI)
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